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Comparison of some clinical and histological features of colorectal carcinoma occurring in patients below and above 40 years

Authors:

MVC de Silva ,

Department of Pathology, Faculty of Medicine, University of Colombo, LK
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MS Fernando,

Department of Pathology, Faculty of Medicine, University of Colombo, LK
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D Fernando

Department of Surgery, Faculty of Medical Sciences, University of Sri Jayawardenepura, LK
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Abstract

Objective To determine the clinicopathological features  of colorectal malignancies in Sri Lankan patients aged 40  years or younger, and to compare them with those of older  patients.

Methods The clinicopathological features of 60 colorectal  malignancies which occurred in patients aged 40 years or  younger were compared with 245 malignant colorectal  tumours in older patients. These tumours had been diagnosed  at a University Department of Pathology over 15  years.

Results 19.7% of colorectal malignancies occurred in patients  aged 40 years or younger. (Male: Female ratio =  1.6:1). The mean duration from onset of symptoms to diagnosis  was 4.2 months. There was no statistically significant  difference between young and old patients in the  presenting symptoms, site of tumour and Dukes' staging  of colorectal malignancies. A statistically significant proportion  of tumours in young patients was mucoid (13.3%)  or signet ring cell (5%) type. 3.3% of young patients with  colorectal carcinoma gave a family history of similar malignancy.  A history of predisposing conditions (ulcerative  colitis) was present in 3.3% of young patients.

Conclusions The clinical presentation of colorectal malignancies  in Sri Lankan patients below 40 years of age  does not differ from that in older patients. Mucoid and  signet ring cell carcinomas are commoner in the young.

 

DOI: http://dx.doi.org/10.4038/cmj.v45i4.6722

Ceylon Medical Journal 2000; 45(4): 166-168

DOI: https://doi.org/10.4038/cmj.v45i4.6722
How to Cite: de Silva, M., Fernando, M. and Fernando, D., 2014. Comparison of some clinical and histological features of colorectal carcinoma occurring in patients below and above 40 years. Ceylon Medical Journal, 45(4), pp.166–168. DOI: http://doi.org/10.4038/cmj.v45i4.6722
Published on 24 Mar 2014.
Peer Reviewed

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