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A patient presenting with features of progressive multifocal leucoencephalopathy in HIV/AIDS

Authors:

AAPT Chang ,

Department of Clinical Medicine, Faculty of Medicine, University of Colombo, LK
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S Jayasinghe,

Department of Clinical Medicine, Faculty of Medicine, University of Colombo, LK
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S Rajapakse,

Department of Clinical Medicine, Faculty of Medicine, University of Colombo, LK
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MHR Sheriff

Department of Clinical Medicine, Faculty of Medicine, University of Colombo, LK
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Abstract

Progressive multifocal leucoencephalopathy (PML) is associated with infection of oligodendrocytes by the papovavirus JC (the initials of the patient whose tissue was used to isolate the virus; not Jakob-Creutzfeldt disease). This leads to demyelination of the white matter. It is characterised by dementia, dysphasia, pyramidal tract involvement and persistently normal CSF analysis. The course is inexorably progressive with many dying within six to nine months of diagnosis. PML prevalence rates of 3 to 5% have been reported in patients with AIDS (1). However, PML as the AIDS defining diagnosis is extremely rare in Asia (2). We report here a patient who presented with neurological manifestations of PML, which is a rare but recognised AIDS indicator condition.

DOI: http://dx.doi.org/10.4038/cmj.v46i4.6468

Ceylon Medical Journal 2001; 46(4): 153

DOI: https://doi.org/10.4038/cmj.v46i4.6468
How to Cite: Chang, A., Jayasinghe, S., Rajapakse, S. and Sheriff, M., 2014. A patient presenting with features of progressive multifocal leucoencephalopathy in HIV/AIDS. Ceylon Medical Journal, 46(4), p.153. DOI: http://doi.org/10.4038/cmj.v46i4.6468
Published on 27 Jan 2014.
Peer Reviewed

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