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Seroconversion after hepatitis B vaccination in healthy young adults, and the effect of a booster dose

Authors:

J Perera ,

Department of Microbiology, Faculty of Medicine, University of Colombo., LK
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B Perera,

Department of Microbiology, Faculty of Medicine, University of Colombo, LK
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S Gamage

Department of Microbiology, Faculty of Medicine, University of Colombo
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Abstract

Objective Previous studies have shown that 5% to 15% of healthy people do not show a protective antibody response following hepatitis B vaccination. The study was done to determine the protective efficacy of vaccination in healthy young adults 1 to 4 years after the three dose vaccination series and to study the effect of a booster dose on nonresponders and hypo-responders.

Design Prospective intervention study.

Setting From January to June 2000, Faculty of Medicine, University of Colombo.

Study group 258 volunteers from five batches of medical students vaccinated with three doses of the recombinant vaccine at 0, 1 and 6 months.

Results 9.5% were non-responders. Duration of vaccination, sex and body mass index were not significantly associated with anti-HBs levels. 28.6% had potential risk factors for acquiring HBV infection. 86.3% of non-responders developed protective anti-HBs titres after a booster dose. The persistent non-responders did not have a chronic illness or past HBV infection.

Conclusions A substantial number do not seroconvert after hepatitis B vaccination. Testing of blood for anti-HBs one month after vaccination is recommended to recognise nonresponders as a booster dose will be beneficial in the majority of them.

 

DOI: http://dx.doi.org/10.4038/cmj.v47i1.6396

Ceylon Medical Journal 2002; 47(1): 6-8
DOI: http://doi.org/10.4038/cmj.v47i1.6396
How to Cite: Perera, J., Perera, B. & Gamage, S., (2014). Seroconversion after hepatitis B vaccination in healthy young adults, and the effect of a booster dose. Ceylon Medical Journal. 47(1), pp.6–8. DOI: http://doi.org/10.4038/cmj.v47i1.6396
Published on 22 Jan 2014.
Peer Reviewed

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