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Hyperhomocysteinaemia in Sri Lankan patients with coronary artery disease

Authors:

Sriyantha Mendis ,

Asiri Hospital, Colombo, LK
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Pramod Ranatunga,

Asiri Hospital, Colombo, LK
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Mohan Jayatilake,

Asha Central Hospital, Colombo, LK
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Sanjeewa Wanninayake,

Asiri Hospital, Colombo, LK
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Rajitha Wickremasinghe

Department of Community Medicine and Family Medicine, Faculty of Medical Sciences, University of Sri Jayewardenapura, Nugegoda, LK
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Abstract

Objective To determine the association between hyperhomocysteinaemia and coronary artery disease (CAD) in a sample of Sri Lankans.

Design A case control study.

Setting Asiri Hospital, Kirula Road, Colombo 5, Sri Lanka.

Subjects 105 patients with coronary artery disease and 112 controls.

Method Fasting serum homocysteine levels were measured in 105 patients diagnosed as having CAD and in 112 unmatched controls. All patients admitted with clinical, electrocardiographical, biochemical or echocardiographical evidence of CAD were included in the study. Controls were selected from subjects admitted for health screening.

Results 105 patients with CAD and 112 controls (unmatched for age and sex) were studied. A serum homocysteine level in excess of 18.2 μmol/l was considered high. Confounding effects of other conventional risk factors for CAD were controlled using multivariate logical regression analysis.

Conclusion Hyperhomocysteinaemia is significantly associated with CAD. Multivariate logistic regression analysis indicated that the association between hyperhomocysteinaemia and CAD was confounded by other risk factors. However, statistical analysis revealed a significant independent association between hyperhomocysteinaemia and CAD (adjusted odds ratio = 2.881).

(Index words: Coronary artery disease, ischaemic heart disease)

DOI: http://dx.doi.org/10.4038/cmj.v47i3.3436

CMJ 2002; 47(3): 89-92

DOI: https://doi.org/10.4038/cmj.v47i3.3436
How to Cite: Mendis, S., Ranatunga, P., Jayatilake, M., Wanninayake, S. and Wickremasinghe, R., 2011. Hyperhomocysteinaemia in Sri Lankan patients with coronary artery disease. Ceylon Medical Journal, 47(3), pp.89–92. DOI: http://doi.org/10.4038/cmj.v47i3.3436
Published on 25 Aug 2011.
Peer Reviewed

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