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Incidence and risk factors for neonatal hypoglycaemia in Kerala, India

Authors:

CK Sasidharan,

Professor and Head, Division of Neonatology, Department of Paediatrics, Institute of Maternal and Child Health, Medical College, Kozhikode, IN
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E Gokul ,

Junior Resident, Division of Neonatology, Department of Paediatrics, Institute of Maternal and Child Health, Medical College, Kozhikode, IN
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S Sabitha

Junior Resident, Division of Neonatology, Department of Paediatrics, Institute of Maternal and Child Health, Medical College, Kozhikode, IN
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Abstract

Objectives To detect the incidence and risk factors that predicted the occurrence of neonatal hypoglycaemia and to identify neonates who require mandatory blood glucose screening during the first 48 h of life.
Design Hospital based prospective study in a maternity centre in south India.
Setting Labour room, postnatal wards and newborn nursery of the Institute of Maternal and Child Health, Medical College, Kozhikode, India.
Patients Six hundred and four neonates were enrolled in the study by a systematic random sampling method from 1 August to 1 November 2002.
Intervention/Measurement Random blood glucose levels were estimated by the standard glucose oxidase- peroxidase method on two occasions 24 h apart, during the first 2 days of life. Nineteen clinical characteristics of the mother-baby pair were analysed statistically in relation to the occurrence of hypoglycaemia.
Results The incidence of neonatal hypoglycaemia in the present study group was 41/1000 live births. Eight variables strongly and independently predicted the risk of neonatal hypoglycaemia, at least one being present in 89.1% of the hypoglycaemic neonates. They included prematurity, low birthweight, maternal diabetes mellitus, delay in initiation of breastfeeding for more than 2 h postnatally, maternal pre-eclampsia and eclampsia, birth asphyxia, cold stress or hypothermia, and maternal oligohydramnios.
Conclusions Hypoglycaemia was a common problem in apparently normal asymptomatic babies. Apart from the classic ‘text book risk factors', maternal oligohydramnios and a breastfeeding delay of more than 2 h after delivery predicted the risk of neonatal hypoglycaemia in this group. Mandatory blood glucose screening in babies with any one of the above mentioned risk factors serves as an easy and cost effective measure for the prompt identification of this condition.

(Index words: High risk neonates; neonatal hypoglycaemia)  

DOI: 10.4038/cmj.v49i4.1919

Ceylon Medical Journal Vol.49(4) 2004 pp.110-113

DOI: https://doi.org/10.4038/cmj.v49i4.1919
How to Cite: Sasidharan, C., Gokul, E. and Sabitha, S., 2010. Incidence and risk factors for neonatal hypoglycaemia in Kerala, India. Ceylon Medical Journal, 49(4), pp.110–113. DOI: http://doi.org/10.4038/cmj.v49i4.1919
Published on 21 May 2010.
Peer Reviewed

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