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Enteric fever caused by Salmonella isolates with decreased susceptibility to ciprofloxacin

Authors:

Lilani Karunanayake ,

Senior Registrar in Medical Microbiology, National Hospital of Sri Lanka, Colombo., LK
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SD Atukorala

Clinical Bacteriologist, National Hospital of Sri Lanka, Colombo., LK
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Abstract

With emerging drug resistance, ciprofloxacin became the frontline antibiotic against Salmonella strains causing enteric fevers worldwide. However, strains with decreased susceptibility to flouroquinolones have recently emerged as a problem in our region. Such strains are not detected by the routine disc diffusion method unless a nalidixic acid disc is also used. They are, however, important clinically since they show poor clinical responses and have higher faecal carriage rates following treatment with fluoroquinolones in usual doses. We report the first two cases of such strains in Sri Lanka, both acquired locally. We recommend the routine use of a nalidixic acid disc in sensitivity testing of Salmonella species, causing enteric fever in laboratories not determining minimum inhibitory concentrations (MICs) for fluoroquinolones in order to detect such strains, so that appropriate clinical decisions regarding antibiotic therapy can be mad

(Index words: Antibiotic sensitivity; nalidixic acid disc; poor response to fluoroquinolones)

DOI: 10.4038/cmj.v49i4.1929

Ceylon Medical Journal Vol.49(4) 2004 pp.137-138

DOI: https://doi.org/10.4038/cmj.v49i4.1929
How to Cite: Karunanayake, L. and Atukorala, S., 2010. Enteric fever caused by Salmonella isolates with decreased susceptibility to ciprofloxacin. Ceylon Medical Journal, 49(4), pp.137–138. DOI: http://doi.org/10.4038/cmj.v49i4.1929
Published on 21 May 2010.
Peer Reviewed

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