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Imported quinine resistant Plasmodium falciparum malaria in Sri Lanka

Authors:

Anula Wijesundere ,

Physician, Sri Jayewardenepura General Hospital (Teaching), Nugegoda, LK
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Panduka Karunanayake,

Physician, Infectious Disease Hospital, Angoda, Sri Lanka, LK
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Inoshi Athukorala,

Registrar, Sri Jayewardenepura General Hospital (Teaching), Nugegoda, LK
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Kaushalya Jasekara

Registrar, Sri Jayewardenepura General Hospital (Teaching), Nugegoda, LK
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Abstract

Chloroquine still remains the first line drug for treatment of uncomplicated Plasmodium falciparum malaria in Sri Lanka. Sulfadoxine-pyrimethamine (S-P. Fansidar) is used as the main second line drug. Quinine is the drug of choice for complicated P. falciparum malaria.

Chloroquine resistant P. falciparum malaria in Sri Lanka was first reported from Dambulla in 1984 [1], and its spread has been identified and reported by the Anti- Malaria Campaign [2]. Resistance to chloroquine and sulfadoxine- pyrimethamine (S-P) has been infrequently reported in Sri Lanka in 1994 [3,4] and in 1996 [5]. More recently, chloroquine resistant P. falciparum malaria has been reported among the security forces personnel in the Mannar district [6].

Quinine resistant P. falciparum malaria has not yet been reported in Sri Lanka. Rare cases of RII and RIII resistance (failure to clear or failure to reduce parasitaemia in the first 7 days) to quinine have been documented in Thailand, Vietnam, tropical Africa and the Amazon region [7-9]. We report here for the first time, imported quinine resistant P. falciparum malaria encountered in Sri Lanka.

Key words: Artemisinin; malaria contracted in Nigeria

DOI: 10.4038/cmj.v50i3.1432

Ceylon Medical Journal Vol.50(3) 2005: 125-126
DOI: https://doi.org/10.4038/cmj.v50i3.1432
How to Cite: Wijesundere, A., Karunanayake, P., Athukorala, I. and Jasekara, K., 2009. Imported quinine resistant Plasmodium falciparum malaria in Sri Lanka. Ceylon Medical Journal, 50(3), pp.125–126. DOI: http://doi.org/10.4038/cmj.v50i3.1432
Published on 09 Dec 2009.
Peer Reviewed

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