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Case Reports

Acute leukaemia of ambiguous lineage – a diagnostic dilemma

Authors:

L V Gooneratne,

Department of Pathology, Faculty of Medicine, Colombo, Sri Lanka, LK
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M D M Wijeratne,

Department of Pathology, Faculty of Medicine, Colombo, Sri Lanka, LK
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H D H S Gunasekara,

Haematology Unit, National Hospital of Sri Lanka., LK
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M N Tudawe

Haematology Unit, National Hospital of Sri Lanka., LK
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Abstract

Acute leukaemia of ambiguous lineage (ALAL) is a rare form of leukaemia in which morphologic, cytochemical and immuno-phenotypic features of the proliferating blasts lack sufficient evidence to classify them as myeloid or lymphoid in origin or have characteristics of both myeloid and lymphoid cells. We report a 22-year old man presenting with clinical features of an acute lymphoblastic leukaemia but blasts in his blood and bone marrow with morphological features of myeloblasts. His immunophenotyping by flowcytometry showed antigens specific for both myeloid and B-lymphoid lineages. We highlight the importance of correlating clinical features with cellular morphology when diagnosing acute leukaemias, especially when facilities for flowcytometry are not routinely available.  

Key words: acute leukaemia, ambiguous, flowcytometry, blasts

doi: 10.4038/cmj.v54i2.866

Ceylon Medical Journal Vol. 54, No. 2, June 2009 pp51-53

DOI: http://doi.org/10.4038/cmj.v54i2.866
How to Cite: Gooneratne, L.V. et al., (2009). Acute leukaemia of ambiguous lineage – a diagnostic dilemma. Ceylon Medical Journal. 54(2), pp.51–53. DOI: http://doi.org/10.4038/cmj.v54i2.866
Published on 24 Jul 2009.
Peer Reviewed

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