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Validation of the Sinhala version of the Chronic Liver Disease Questionnaire (CLDQ) for assessment of health related quality of life among Sri Lankan cirrhotics

Authors:

CK Ranawaka,

University Medical Unit, Colombo North Teaching Hospital, LK
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JKND Miththinda ,

University Medical Unit, Colombo North Teaching Hospital, LK
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SM Senanayake,

University Medical Unit, Colombo North Teaching Hospital, LK
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WRS de Alwis,

Department of Medicine, Faculty of Medicine, University of Kelaniya, LK
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MNF Mufeena,

Department of Medicine, Faculty of Medicine, University of Kelaniya, LK
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MA Niriella,

Department of Medicine, Faculty of Medicine, University of Kelaniya. University Medical Unit, Colombo North Teaching Hospital, LK
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AS Dassanayake,

Department of Pharmacology, Faculty of Medicine, University of Kelaniya, LK
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AP de Silva,

Department of Medicine, Faculty of Medicine, University of Kelaniya. University Medical Unit, Colombo North Teaching Hospital, LK
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A Pathmeswaran,

Department of Public Health, Faculty of Medicine, University of Kelaniya, LK
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HJ de Silva

Department of Medicine, Faculty of Medicine, University of Kelaniya. University Medical Unit, Colombo North Teaching Hospital, LK
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Abstract

Objectives The Chronic Liver Disease Questionnaire (CLDQ) is a validated tool measuring Health Related Quality of Life among patients with cirrhosis. The aim of this study was to validate a Sinhala version of the CLDQ (sCLDQ) and to test its correlation with the degree of liver dysfunction in a cohort of Sri Lankan patients with cirrhosis.

Methods A standard translation method was used. Pilot testing was done with relevant cultural and language adaptations. The final version and the WHO Quality of Life-BREF (WHOQOL-BREF) validated Sinhala version were administered to patients with chronic lever disease (CLD). sCLDQ was re-administered 4 weeks later to test internal consistency and reliability. The validaty and reliability were assessed by Cronabach’s alpha, intraclass correlation coefficient (ICC) and Pearson's correlation coefficient. ANOVA and Pearson's correlation were used to assess correlation with the degree of liver dysfunction.

Results Validation was done with 214 participants [mean age 55.6 years (SD 10.4) male 77.6%]. Cronabach’s alpha was 0.926. Intra-class correlations varied from 0.431 to 0.912 and all were significant (p< 0.001). Retesting was done on a sub-sample of 18 participants. Test-retest correlation was 0.695 (p = 0.008). WHO-BREF was administered to a sub-sample of 48 subjects. There was a significant correlation (Pearson’s r=0.391; p=0.004) between sCLDQ and WHOQOL BREF. sCLDQ was significantly associated with MELD (r=-0.13; p=0.038), MELD sodium (r=-0.223; p=0.002), serum bilirubin (r=-0.124; p=0.036), serum sodium (r=0.172; p=0.009), serum albumin (r=0.201; p=0.003) and Child grade (f=3.687; p=0.027).

Conclusions CLDQ is a reliable and valid tool to assess quality of life of Sri Lankan patients with cirrhosis and correlates well with known indices of disease severity.

DOI: http://dx.doi.org/10.4038/cmj.v58i4.5612

Ceylon Medical Journal 2013; 58: 156-162

DOI: https://doi.org/10.4038/cmj.v58i4.5612
How to Cite: Ranawaka, C., Miththinda, J., Senanayake, S., de Alwis, W., Mufeena, M., Niriella, M., Dassanayake, A., de Silva, A., Pathmeswaran, A. and de Silva, H., 2013. Validation of the Sinhala version of the Chronic Liver Disease Questionnaire (CLDQ) for assessment of health related quality of life among Sri Lankan cirrhotics. Ceylon Medical Journal, 58(4), pp.156–162. DOI: http://doi.org/10.4038/cmj.v58i4.5612
Published on 28 Dec 2013.
Peer Reviewed

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