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Reading: HLA-B27 allele frequency in Sri Lankan patients with spondyloarthritides

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HLA-B27 allele frequency in Sri Lankan patients with spondyloarthritides

Authors:

S Kidnapillai,

Human Genetics Unit, Faculty of Medicine, University of Colombo, Sri Lanka., LK
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N D Sirisena,

Human Genetics Unit, Faculty of Medicine, University of Colombo, Sri Lanka., LK
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V H W Dissanayake

Human Genetics Unit, Faculty of Medicine, University of Colombo and Asiri Centre for Genomic and Regenerative Medicine, Asiri Surgical Hospital, Colombo, Sri Lanka., LK
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Abstract

This preliminary study aims to describe the HLA-B27 allele frequency in Sri Lankan patients with spondyloarthritides (SA). An anonymised database of 373 Sri Lankan patients with SA referred for HLA-B27 testing was retrospectively analysed. Eighty five (22.8%) patients were positive for the HLA-B27 allele. A male preponderance was observed among the positives. The HLA-B27 allele frequency in this sample of patients with SA was relatively low compared to published studies in other populations. Further research is needed to identify the predominant subtypes of the allele to determine which subtypes are the most prevalent in a larger sample of Sri Lankan patients with SA, and to define their association with the specific types of SA.

DOI: https://doi.org/10.4038/cmj.v61i2.8287
How to Cite: Kidnapillai, S., Sirisena, N.D. and Dissanayake, V.H.W., 2016. HLA-B27 allele frequency in Sri Lankan patients with spondyloarthritides. Ceylon Medical Journal, 61(2), pp.71–73. DOI: http://doi.org/10.4038/cmj.v61i2.8287
Published on 23 Jun 2016.
Peer Reviewed

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