Start Submission Become a Reviewer

Reading: Effects of 5 IU oxytocin bolus and 20 IU oxytocin infusion compared to 5 IU oxytocin bolus a...

Download

A- A+
dyslexia friendly

Papers

Effects of 5 IU oxytocin bolus and 20 IU oxytocin infusion compared to 5 IU oxytocin bolus and normal saline infusion in the control of blood loss during and after ante-partum lower segment caesarean section: a randomized controlled trial

Authors:

J Kajendran ,

Obstetrics and Gynaecology Unit, Teaching Hospital Peradeniya, Peradeniya, LK
X close

G R C Silva,

Obstetrics and Gynaecology Unit, Teaching Hospital Peradeniya, Peradeniya, LK
X close

S K Ranaraja

Obstetrics and Gynaecology Unit, Teaching Hospital Peradeniya, Peradeniya, LK
X close

Abstract

Introduction Obstetric haemorrhage is the leading cause of maternal mortality worldwide and in most cases it relates to uterine atony. Even though an oxytocin bolus is used routinely, additional infusion of oxytocin may be required if haemorrhage occurs.


Objectives To compare the effects of 20 IU oxytocin infusion and 5 IU bolus with 5 IU bolus and 500ml normal saline on the control of blood loss in ante-partum lower segment caesarean section.


Methods A double-blind randomized controlled trial was conducted in the Teaching Hospital, Peradeniya, Sri Lanka. Ninety two pregnant women, forty six from each group were randomized to receive either intravenous slow 5 IU oxytocin bolus over 1 minute and additional 20 IU oxytocin infusion in 500 ml of 0.9% saline solution over 4 hours (Group-A) or 5 IU oxytocin bolus over 1 minute and 500 ml of 0.9% Saline over 4 hours (Group B). Visual assessment of mean blood loss was done by the surgeon and anaesthetist. Blood loss was calculated based on the body weight and haematocrit before and 48 hours after delivery. Other outcome measures were mean blood loss, major obstetric haemorrhage (>1000 ml), need of additional uterotonics and blood transfusions.


Results Calculated mean blood loss (456.0ml vs 569.8ml) was significantly less in group A (p=0.046). Visual estimation of blood loss by surgeon (476.9 vs 552.1) (p=0.01) and anaesthetist  (492.7 vs 557.2) (p= 0.03) were also significantly less in group A.


Conclusion Additional oxytocin infusion at ante-partum caesarean section reduces blood loss during and after caesarean section significantly. 

How to Cite: Kajendran, J., Silva, G.R.C. & Ranaraja, S.K., (2017). Effects of 5 IU oxytocin bolus and 20 IU oxytocin infusion compared to 5 IU oxytocin bolus and normal saline infusion in the control of blood loss during and after ante-partum lower segment caesarean section: a randomized controlled trial. Ceylon Medical Journal. 62(3), pp.121–127. DOI: http://doi.org/10.4038/cmj.v62i3.8515
Published on 25 Sep 2017.
Peer Reviewed

Downloads

  • PDF (EN)

    comments powered by Disqus