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Reading: The -31 G/C promoter gene polymorphism of surviving in Turkish colorectal cancers patients

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The -31 G/C promoter gene polymorphism of surviving in Turkish colorectal cancers patients

Authors:

M Budak ,

Cerrahpasa Medical Faculty- Istanbul, TR
About M

Department of Biophysics, Istanbul University

Department of Biophysics, Trakya University, Medical Faculty-Edirne, Turkey


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C Bozkurt,

Cerrahpasa Medical Faculty- Istanbul, TR
About C
Molecular Pathology Laboratory, Istanbul University
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S E Cetin,

Cerrahpasa Medical Faculty- Istanbul, TR
About S
Department of Pathology, Istanbul University
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H Tuncel

Cerrahpasa Medical Faculty- Istanbul, TR
About H
Department of Biophysics, Istanbul University
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Abstract

Introduction

Survivin (also known as birc5) is the first protein discovered among the apoptosis-regulating gene family referred to as inhibitor of apoptosis proteins (IAPs). It is expressed and controlled during cellular differentiation and development in human beings. Survivin expression has been shown in a number of cancers and has been associated with cancer development.

Objective

In our study, we compared with blood samples as our control and normal- tumoural tissue samples, which obtained from the same tissue of 100 cases diagnosed with colorectal cancer, at Department of Pathology, Istanbul University.

Methods

The present study employed PCR-RFLP to identify the -31 G/C polymorphism in the promoter region of the survivin gene.  Distribution of the survivin polymorphism was compared between control and tumoural tissue samples using the chi-square test.

Results

Comparison of all samples revealed that there was significant difference in distribution of survivin promoter -31G/C between control group and tumour and normal tissue of the patient group (p<0.05). When genotypes of the control and tumour tissues were compared according to gender, there was no statistically significant difference in the distribution of survivin promoter -31G/C in females p=0.420 or males p=0.309.

Conclusion

A significant difference was seen in distribution of C allele in tumour tissue compared to normal tissue.

DOI: https://doi.org/10.4038/cmj.v63i3.8714
How to Cite: Budak, M., Bozkurt, C., Cetin, S.E. and Tuncel, H., 2018. The -31 G/C promoter gene polymorphism of surviving in Turkish colorectal cancers patients. Ceylon Medical Journal, 63(3), pp.151–155. DOI: http://doi.org/10.4038/cmj.v63i3.8714
Published on 30 Sep 2018.
Peer Reviewed

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