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Original article

Association between visceral adiposity index, hirsutism and cardiometabolic risk factors in women with polycystic ovarian syndrome: A cross-sectional study

Authors:

Sanjeewani Fonseka ,

University of Peradeniya, LK
About Sanjeewani
Department of Pharmacology, Faculty of Medicine
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Brabaharan Subhani,

University of Peradeniya, LK
About Brabaharan
Department of Pharmacology, Faculty of Medicine
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Chandrika N. Wijeyaratne,

University of Colombo, LK
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Indika B. Gawarammana,

University of Peradeniya, LK
About Indika B.
Department of Medicine, Faculty of Medicine
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Nishan S. Kalupahana,

University of Peradeniya, LK
About Nishan S.
Department of Physiology, Faculty of Medicine
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Neelakanthi Ratnatunga,

University of Peradeniya, LK
About Neelakanthi
Department of Pathology, Faculty of Medicine
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Shanthini Rosairo,

University of Peradeniya, LK
About Shanthini
Department of Radiology, Faculty of Medicine
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Kumarasiri P. Vithane

University of Peradeniya, LK
About Kumarasiri P.
Faculty of Medicine,
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Abstract

Introduction

Visceral adiposity index (VAI) is a mathematical index derived from the body mass index (BMI), waist circumference (WC), serum fasting triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C). It reflects visceral adipocyte dysfunction (VAD) and is associated with cardiometabolic risk. Women with polycystic ovarian syndrome (PCOS) have adipocyte dysfunction, which is associated with metabolic disorders. Hirsutism in PCOS is considered to be due to high insulin levels which enhances androgen activity at the pilosebaceous unit.


Objectives

To determine the association between VAI, hirsutism and cardiometabolic risk factors in patients with PCOS.


Methods

A total of 99 patients aged 18-40 years with PCOS diagnosed by the Rotterdam consensus criteria-2003 and a hirsutism score of 8 or more according to the Ferriman-Gallway Score (FGS) were studied.  BMI, WC, fasting lipid profile, serum leptin, insulin, sex hormone binding globulin (SHBG), free-androgen index (FAI), fasting blood glucose (FBG) and oral glucose tolerance test (OGTT) were determined. Homeostasis model assessment (HOMA)-beta, HOMA-insulin resistance (IR) and VAI were calculated. Diameter and rate of hair growth at sideburns and chin; density of hair at sideburns were measured. Data were analyzed by SPSS-22.0.


Results

There was no significant association between parameters of hirsutism and VAI. There was a significant association between VAI and OGTT, FAI, systolic and diastolic blood pressure: but not between VAI and other metabolic parameters.


Conclusion

Visceral adipocyte dysfunction is closely linked to glucose intolerance and blood pressure in women with PCOS. However, hirsutism is unlikely to be due to adipocyte dysfunction.

DOI: https://doi.org/10.4038/cmj.v64i3.8958
How to Cite: Fonseka, S., Subhani, B., Wijeyaratne, C.N., Gawarammana, I.B., Kalupahana, N.S., Ratnatunga, N., Rosairo, S. and Vithane, K.P., 2019. Association between visceral adiposity index, hirsutism and cardiometabolic risk factors in women with polycystic ovarian syndrome: A cross-sectional study. Ceylon Medical Journal, 64(3), pp.111–117. DOI: http://doi.org/10.4038/cmj.v64i3.8958
Published on 30 Sep 2019.
Peer Reviewed

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