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Original article

Association of Serum Uric acid and Gamma-glutamyltransferase with Obesity Related Metabolic Derangements in a Cohort of Children with Obesity in Sri Lanka

Authors:

Dinesha M. Vidanapathirana ,

Lady Ridgeway Hospital for Children, Colombo, LK
About Dinesha M.
Department of Chemical Pathology
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Eresha A. Jasinge,

Lady Ridgeway Hospital for Children, Colombo, LK
About Eresha A.
Department of Chemical Pathology
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Dulani Samaranayake,

University of Colombo, LK
About Dulani
Faculty of Medicine, Department of Community Medicine
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Pujitha Wickramasinghe

University of Colombo
About Pujitha
Faculty of Medicine, Department of Community Medicine
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Abstract

Introduction: Gamma-glutamyltransferase (GGT) and serum uric acid (UA) are known to be associated with cardiovascular disease in obese children.

 

Objectives: To determine the association of serum UA and GGT with components of metabolic syndrome (MetS) in a group of obese children and determine the validity of UA and GGT in predicting MetS.

 

Methods: Cross sectional analytical study was conducted among 205, 5-15 year old obese children. After a 12- hour overnight fast, blood was drawn for glucose, lipid profile, alanine aminotransferase (ALT), aspartate aminotransferase (AST), insulin, UA and GGT. Oral glucose tolerance test (OGTT) was done with 2 hour plasma glucose. Height, weight, waist circumference,

blood pressure and fat mass were measured. USS of abdomen was performed to assess hepatic steatosis.

 

Results: Chi square test showed statistically significant associations between GGT and UA with triglyceride, insulin resistance (HOMA-IR), AST, ALT, AST/ALT ratio and fatty liver. Additionally UA showed a significant association with the OGTT. With existing cut offs (GGT >30 U/L and UA >330 μmol/L) the sensitivity and specificity of GGT in predicting MetS was 19% (95% CI, 13.63-24.37) and 88.4% (95% CI, 84.02-92.78) respectively while for UA was 28.6% (95% CI, 22.42-34.78) and 80.2% (95% CI, 74.75-85.65) respectively. A new cut off value of 19.5 U/L (sensitivity 56% and specificity 55%) for GGT and 275.5 μmol/L (sensitivity 61% and specificity 54%) for UA predicted MetS with greater accuracy.

 

Conclusion: GGT and UA are strongly associated with metabolic derangements and these biomarkers are rather weak in predicting MetS.

DOI: https://doi.org/10.4038/cmj.v64i4.8989
How to Cite: Vidanapathirana, D.M., Jasinge, E.A., Samaranayake, D. and Wickramasinghe, P., 2019. Association of Serum Uric acid and Gamma-glutamyltransferase with Obesity Related Metabolic Derangements in a Cohort of Children with Obesity in Sri Lanka. Ceylon Medical Journal, 64(4), pp.125–132. DOI: http://doi.org/10.4038/cmj.v64i4.8989
Published on 31 Dec 2019.
Peer Reviewed

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