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Estimation of prevalence of red cell alloantibodies in patients with Beta Thalassaemia Major in Sri Lanka.

Authors:

Samantha Senavirathna ,

Ministry of Health, LK
About Samantha
National Blood Transfusion Service
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Lakmali Ranasinghe,

Ministry of Health, LK
About Lakmali
National Blood Transfusion Service
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Yashobha Thilakarathne

Ministry of Health, LK
About Yashobha
National Blood Transfusion Service
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Abstract

Background and objectives: Major beta thalassaemia is an inherited haemolytic disease that needs regular blood transfusion as a standard treatment. Blood transfusion is generally safe; however, adverse effects can occur and one of which is red cell alloimmunization that can lead to acute or delayed haemolytic transfusion reactions. This study was designed to estimate the prevalence of red cell alloantibodies in patients with thalassaemia in Sri Lanka.

 

Methods: The study was carried out at three tertiary care hospitals of Sri Lanka. Every beta thalassaemia patients transfused with packed red cells were included. Data collected to a form by analysing the cross match request form sent to the blood bank prior to the transfusion.

 

Results: There were 398 patients in all hospitals. 188 (47.24%) of them were males and 210 (52.76%) were females. Mean age was 18.41 (SD=11.67) years. Out of 398 patients, unexpected red cell antibodies are present only in 6 (1.51%) patients. Identified antibodies were Anti E, Anti K, Anti D, Anti C, Anti S, Anti Jkb and autoantibodies. There was one patient who had developed multiple antibodies.

 

Conclusion: Prevalence of red cell antibodies is lower, even though the patients were been transfused without phenotypically matched red cells. Further studies are suggested to decide the practice of Rh and Kell matching for transfusion in patients with beta thalassaemia.

DOI: https://doi.org/10.4038/cmj.v66i2.9472
How to Cite: Senavirathna, S., Ranasinghe, L. and Thilakarathne, Y., 2021. Estimation of prevalence of red cell alloantibodies in patients with Beta Thalassaemia Major in Sri Lanka.. Ceylon Medical Journal, 66(2), pp.96–99. DOI: http://doi.org/10.4038/cmj.v66i2.9472
Published on 20 Dec 2021.
Peer Reviewed

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