Start Submission Become a Reviewer

Reading: Serotyping of invasive and colonizing group B Streptococcus (GBS) isolates at selected hospi...

Download

A- A+
Alt. Display

Original articles

Serotyping of invasive and colonizing group B Streptococcus (GBS) isolates at selected hospitals in Sri Lanka : a multicenter study

Authors:

Rasika Chinthamani ,

Postgraduate Institute of Medicine, LK
X close

Sujatha Pathirage,

Medical Research Institute, LK
X close

Shirani Chandrasiri

Colombo South Teaching Hospital, Kalubowila, LK
X close

Abstract

Introduction: Group B Streptococcus (GBS) causes significant morbidity and mortality in neonates, pregnant women and patients with underlying comorbidities. Intrapartum antibiotic prophylaxis (IAP) is currently the mainstay of prevention and effective vaccine against invasive GBS disease is under clinical trial.


Objectives: To describe the serotype distribution of invasive and colonizing GBS isolates in Sri Lanka


Methods: Probable GBS isolates from high vaginal swabs (HVS) and sterile body sites were collected from eight selected hospital laboratories. Following confirmation of the identification as group B Streptococcus by phenotypic methods including Lancefield grouping test (Plasmatic UK), isolates were tested for serotyping by latex agglutination test kit (STATEN serum institute, Denmark).


Results: Out of the 145 probable GBS isolates only 100 from HVS and 37 from sterile body sites were confirmed as GBS. Serotype III was the most predominant in invasive GBS isolates followed by Ia, Ib, VI, II and V in the descending order of frequency. Serotype VI was the most predominant in HVS isolates followed by serotype III, V, Ia, II, Ib and IV. Difference of GBS serotype distribution between the invasive and HVS group was statistically significant ( P value = 0.038)


Conclusion: Serotype distribution pattern of the study isolates was comparable to most of the other developing and developed countries and hence will be beneficial in future vaccine introduction. GBS vaccine which is currently under clinical trial (Ia, Ib and III) is potentially effective for preventing 68% of the early onset disease in neonates in this study setting.

DOI: https://doi.org/10.4038/cmj.v66i3.9493
How to Cite: Chinthamani, R., Pathirage, S. and Chandrasiri, S., 2021. Serotyping of invasive and colonizing group B Streptococcus (GBS) isolates at selected hospitals in Sri Lanka : a multicenter study. Ceylon Medical Journal, 66(3), pp.144–150. DOI: http://doi.org/10.4038/cmj.v66i3.9493
Published on 27 Dec 2021.
Peer Reviewed

Downloads

  • PDF (EN)

    comments powered by Disqus