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A report of haploidentical allogeneic haematopoietic stem cell transplantation for inherited bone marrow failure in Sri Lanka

Authors:

Wasanthi Wickramasinghe ,

University of Colombo, LK
About Wasanthi
Faculty of Medicine
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Revathi Raj,

Apollo Children Hospital, IN
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Shama Goonatillake,

Asiri Surgical Hospital, LK
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Anuja Abayadeera,

University of Colombo, LK
About Anuja
Faculty of Medicine
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Malik Samarasinghe,

University of Colombo, LK
About Malik
Faculty of Medicine
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Jeewaka Galhenage,

National Blood Transfusion Services, LK
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Pavithra Aarewatte,

Lady Ridgeway Hospital for Children, LK
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Devan Mendis,

Lady Ridgeway Hospital for Children, LK
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Chandima Thevarapperuma,

Lady Ridgeway Hospital for Children, LK
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Ruwangi Dissanayake,

University of Colombo, LK
About Ruwangi
Faculty of Medicine
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Lallindra Gooneratne

University of Colombo, LK
About Lallindra
Faculty of Medicine
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Abstract

Bone marrow failure (BMF) in children can be idiopathic (70-80%) or inherited. Haematopoietic stem cell transplantation (HSCT) is the only cure for both causes.

 

Allogeneic HSCT requires a suitable donor. Many children will not have a HLA matched sibling or unrelated donor. A haploidentical donor is available for all children as eaazch parent will have at minimum a 50% HLA match.

 

This report of a 7-year old girl with BMF treated with a haplo-HSCT, the first in Sri Lanka, highlights the importance of developing a haploidentical HSCT programme as a potential cure for a disease with a dismal outcome.

DOI: https://doi.org/10.4038/cmj.v67i1.9554
How to Cite: Wickramasinghe, W., Raj, R., Goonatillake, S., Abayadeera, A., Samarasinghe, M., Galhenage, J., Aarewatte, P., Mendis, D., Thevarapperuma, C., Dissanayake, R. and Gooneratne, L., 2022. A report of haploidentical allogeneic haematopoietic stem cell transplantation for inherited bone marrow failure in Sri Lanka. Ceylon Medical Journal, 67(1), pp.17–19. DOI: http://doi.org/10.4038/cmj.v67i1.9554
Published on 04 May 2022.
Peer Reviewed

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