Original articles
Demographics, pathological characteristics and survival in urothelial bladder cancer in a cohort of Sri Lankan patients
Authors:
Ajith Peiris Malalasekera ,
University of Colombo, LK
About Ajith Peiris
Faculty of Medicine
Dileepa Ediriweera,
University of Kelaniya, LK
About Dileepa
Faculty of Medicine
Serozsha A. S. Goonewardena,
National Hospital of Sri Lanka, LK
Neville D. Perera,
National Hospital of Sri Lanka, LK
Anuruddha Abeygunasekara,
Colombo South Teaching Hospital, LK
Rohan W. Jayasekara,
University of Colombo, LK
About Rohan W.
Faculty of Medicine
Kalum Wettasinghe,
University of Colombo, LK
About Kalum
Faculty of Medicine
Vajira H. W. Dissanayake,
University of Colombo, LK
About Vajira H. W.
Faculty of Medicine
Menaka Dilani S. Lokuhetty
University of Colombo, LK
About Menaka Dilani S.
Faculty of Medicine
Abstract
Introduction: Bladder cancer has the 9th highest incidence among Sri Lankan males. This study describes the demographic profiles and survival in bladder cancer patients at two tertiary care centres in Sri Lanka.
Methods: A group of patients with urothelial bladder cancer, presenting for the first time for definitive treatment, were prospectively enrolled from 2013 to 2017.
Results: There were sixty-six patients, with median age of 65 years and male to female ratio of 7:1. Histopathologically pTa 24%, pT1 47% and pT2 29%. Of the pT1 tumours 61% were low grade (LG). The majority (71%) of non-muscle invasive bladder cancer (NMIBC) patients underwent transurethral resection of bladder tumour only.
For the entire cohort the 5-year overall survival was 59% and cancer specific survival (CSS) was 65%. CSS in NMIBC was 75% and 30% in muscle invasive bladder cancer (MIBC). The 5-year female CSS (22%) was significantly lower than in males (71%).
Conclusion: Our cohort has a high male to female ratio. The percentage of MIBC was lower than reported in previous Sri Lankan studies. Of the pT1 tumours there is a higher percentage of pT1 LG patients in comparison to Western reports. There is low utilisation of intravesical mitomycin / bacillus Calmette–Guérin (BCG) in the treatment of NMIBC. The 5-year CSS in the Sri Lankan (lower middle-income economy) cohort lies between the values of high-income economies and upper middle-income economies in Asia. The reasons for poor CSS among Sri Lankan women with bladder cancer needs to be further investigated.
How to Cite:
Malalasekera, A.P., Ediriweera, D., Goonewardena, S.A.S., Perera, N.D., Abeygunasekara, A., Jayasekara, R.W., Wettasinghe, K., Dissanayake, V.H.W. and Lokuhetty, M.D.S., 2022. Demographics, pathological characteristics and survival in urothelial bladder cancer in a cohort of Sri Lankan patients. Ceylon Medical Journal, 67(3), pp.81–88. DOI: http://doi.org/10.4038/cmj.v67i3.9694
Published on
30 Dec 2022.
Peer Reviewed
Downloads
